About us
Genext is a biotechnology company dedicated to developing special nano-drug delivery platforms. Aim to improve the properties of drugs and achieve even seemingly impossible effects in medical treatments. For example, liposomal products can enhance the pharmacokinetic characteristics of drugs, prolonging half-life and reducing toxicity by several orders of magnitude. Nucleic acid drugs, which have received significant attention in recent years, rely on Lipid NanoParticles drug delivery vehicles to enter human cells safely and achieve therapeutic benefits. Additionally, gold nanoparticles can also serve as a radiation sensitizer and utilize radiation to eliminate cancer cells within tumors, thereby enhancing the therapeutic effect.
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Technical platform
The Genext team has established an integrated value chain to meet the current demands and complexities of drug development.
Platforms
Lipid NanoParticles (LNPs)
Nucleic acid drugs have opened the door to a new world of medicine! The nucleic acid vaccine that relieved the Covid-19 pandemic surprised people with the powerful benefits of nucleic acid drugs, as well as introduced the era of nucleic acid drugs! Dr. Giuseppe Ciaramella, chief technology officer of Moderna, which develops a Covid-19 vaccine, once said “Without LNPs, there would be no mRNA vaccines for COVID-19!” “Modern LNPs can be traced back to work on simpler systems called liposomes”, one of the inventors of LNP, Professor Pieter Cullis, explained.
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Platforms
Nano Gold
Our experiment has shown that nano gold particles can enhance the radiation-induced cell death in cancer cells. This means that nano gold particles have a radiation-enhancing effect. The Genext team is focused on developing nano gold as a radiation enhancer for cancer radiotherapy. This kind of treatment is very beneficial for radiation therapy that is difficult to achieve by surgical resection, such as head and neck cancer radiotherapy. By injecting an appropriate amount of nano gold into the affected area, these nano gold particles can provide radiation enhancement benefits throughout a series of treatments.
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Platforms
Liposome
Liposomes are currently the most successful and renowned special drug delivery platform! This is because it is a formulation platform with the capability to significantly improve the pharmacokinetic properties of drugs, and several products formulated with it have successfully entered the market. More importantly, due to a noticeable enhancement in the original drug's efficacy, several products have almost replaced the original drugs in the market, such as Doxil® (Doxorubicin Liposomal Injection) and AmBisome® (Amphotericin B Liposomal Injection).
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